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目的探讨放射性脑病(REP)发生的高危因素和MRI在REP早期诊断中的价值。方法回顾性分析我院近年106例REP患者的临床资料,将发病时间、照射疗程和剂量与MRI影像学检查相结合进行分析。结果 REP发病时间多集中在首次放疗后1～5年,射野上界在OM线上>2.5cm者及生物效应剂量(BED)>139Gy者易发生REP;15.09%的患者尚未出现明显神经系统损害表现时,MRI检查提示为T1WI等或低信号、T2WI高信号。结论对病人采取合理配比照射区域和次数可减少REP的发生,MRI检查有助于早期发现和诊断REP。
Objective To investigate the risk factors of radioactive brain disease (REP) and the value of MRI in the early diagnosis of REP. Methods The clinical data of 106 cases of REP patients in our hospital were retrospectively analyzed. The time of onset, course of radiation and dose were analyzed with MRI. Results The onset time of REP was mostly concentrated between 1 and 5 years after the first radiotherapy. REP patients were found to be REP more than 2.5 cm on the OM line and> 139 Gy on the OM line. No obvious neurological damage occurred in 15.09% of the patients Performance, MRI examination prompted for T1WI or low signal, T2WI high signal. Conclusion The reasonable proportion of patients irradiated area and the number of times can reduce the occurrence of REP, MRI can help early detection and diagnosis of REP.