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目的了解正常儿童唾液中sIgA、IL-6与TNF-α的含量及其相互关系。方法采取随机整群抽样的方法对陕西农村391名出生至18个月婴幼儿进行调查,并对其中55名婴幼儿采用ELISA方法检测唾液中sIgA、IL-6与TNF-α的含量及其粪便中sIgA含量。结果0~18个月龄婴幼儿sIgA(B组48.29700±55.28781)、IL-6(B组100.36200±22.79248)与TNF-α(B组199.05850±182.18959)的均数随年龄增大而变化的趋势基本一致,在B组(4~6月)中均为最高,但统计学分析无显著性差异(P>0.05),1岁后趋于平稳;且唾液中sIgA含量与母乳喂养量、粪便sIgA含量无明显相关性。结论0~18个月龄的婴幼儿唾液中sIgA、IL-6、TNF-α水平均较低,局部免疫功能较差,因此容易发生病毒及细菌的感染,应提高6个月后辅食的质和量,促进婴幼儿生长发育。但是唾液检测并不能代替粪便中sIgA检测,特别不适用于婴幼儿胃肠道功能及胃肠病(腹泻病等)的监测。
Objective To investigate the contents and correlations of sIgA, IL-6 and TNF-α in saliva of normal children. Methods A total of 391 infants from 18 to 18 months old were surveyed by random cluster sampling method in 55 rural infants in Shaanxi Province. The contents of sIgA, IL-6 and TNF-α in saliva and its stool SIgA content. Results The trend of sIgA (48.29700 ± 55.28781 in group B), IL-6 (100.36200 ± 22.79248 in group B) and TNF-α (199.05850 ± 182.18959 in group B) with age increased in 0 ~ 18 months old infants (P> 0.05). After 1 year of age, they tended to be stable; and sIgA content in saliva and breastfeeding, stool sIgA No significant correlation between content. Conclusion The sIgA, IL-6 and TNF-α levels in saliva from 0 to 18 month-old children are lower than those in the control group. Local immune function is poor. Therefore, virus and bacterial infections are easy to occur. The quality of complementary food should be improved after 6 months And quantity, to promote the growth of infants and young children. However, saliva test does not replace sIgA in stool test, especially for infants and young children gastrointestinal function and gastrointestinal diseases (diarrhea, etc.) monitoring.