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目的:研究经方旋覆花汤加维吾尔药苦豆子——旋覆花苦豆子合剂对小鼠肝纤维化的防治作用。方法:40%CCL4花生油皮下注射5周致小鼠肝纤维化,旋覆花汤、苦豆子煎剂和旋覆花苦豆子合剂用药6周后观察其对小鼠肝组织病理变化、ALT和透明质酸的影响。结果:三者均能减轻CCL4引起的肝坏死病变,降低ALT和透明质酸。结论:三者都具有防治肝纤维化的作用,旋覆花汤与苦豆子具有协同作用,能增强防治肝纤维化的作用。
OBJECTIVE: To study the preventive and therapeutic effects of Jingbianhuahuatang plus Uighur medicine Sophora alopecuroides, inulin and bitter bean mixture, on hepatic fibrosis in mice. METHODS: Liver fibrosis was induced by subcutaneous injection of 40% CCL4 peanut oil for 5 weeks, and the pathological changes, ALT, and transparency of liver tissue were observed in mice after 6 weeks of treatment with Xuanfuhua Decoction, Kudoudou Decoction and Inulahuakuzi Mixture. The effect of acidity. Results: All of the three methods can reduce the hepatic necrosis caused by CCL4 and reduce ALT and hyaluronic acid. Conclusion: All three have the effect of prevention and treatment of hepatic fibrosis, and Inulahuatang and Sophora alopecuroides have a synergistic effect, which can enhance the prevention and treatment of hepatic fibrosis.