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[目的]观察鲜葛花汁对大鼠急性酒精性肝损伤的预防保护作用。[方法]以单味葛花汤、益肝灵为对照,各组大鼠均先给予相应的药物灌胃,0.5 h后以白酒灌胃造成急性酒精性肝损伤模型,每天2次,连续灌胃7 d,第7天处死全部大鼠,检测血清和肝组织丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST),同时光镜观察肝组织病理形态学的改变。[结果]鲜葛花汁能有效降低急性酒精性肝损伤模型大鼠血清及肝组织ALT、AST的升高,且作用显著优于对照组(P<0.01);同时对大鼠肝组织病理形态学改变具有明显改善作用。[结论]鲜葛花汁可用于治疗酒精及其他原因引起的肝损伤。
[Objective] To observe the preventive and protective effects of Xian Ge flower juice on acute alcoholic liver injury in rats. [Methods] Single-flavored Gehua Decoction and Yiganling were used as controls. The rats in each group were given the corresponding drugs by gavage first. After 0.5 h, the model of acute alcoholic liver injury was induced by intragastric administration of white wine, twice a day, continuous irrigation. On the 7th day of the stomach, all rats were sacrificed on the 7th day. Serum and hepatic tissue alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected. At the same time, pathological changes of liver tissue were observed by light microscopy. [Results] Fresh Pueraria juice could effectively reduce the serum and hepatic ALT and AST levels in rats with acute alcoholic liver injury, and the effect was significantly better than that in the control group (P<0.01). Changes in learning have a significant improvement. [Conclusion] The fresh flower juice can be used to treat liver injury caused by alcohol and other causes.