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目的探讨D-二聚体(D-dimer,D-D)、同型半胱氨酸(homocysteine,Hcy)和超敏-C反应蛋白(high-sensitivity CRP,hs-CRP)联合检测与子痫前期(Preeclampsia,PE)并发弥散性血管内凝血(Disseminated Intravascular Coagulation,DIC)的相关性。方法选取107例子痫前期患者(PE组),其中31例为重度子痫前期并发DIC患者(DIC组),39例为重度子痫前期患者(重度PE组),37例为轻度子痫前期患者(轻度PE组),110例正常妊娠孕妇作为对照组,分别检测D-二聚体、Hcy和hs-CRP,并用SPSS 19.0软件对结果进行分析比较。结果 PE组与对照组比较、DIC组与重度PE组和轻度PE组相比较、重度PE组与轻度PE组比较,D-二聚体、Hcy和hs-CRP差异均有统计学意义(P<0.01)。PE组、DIC组D-二聚体与Hcy及hs-CRP呈正相关(r=0.758、0.795,P<0.01)、(r=0.839、0.822,P<0.01),且D-二聚体、Hcy及hs-CRP浓度与PE病情轻重呈正相关(r=0.481、0.731、0.548,P<0.01)。结论 D-二聚体、Hcy及hs-CRP升高与子痫前期患者血管内皮损伤存在密切的关系,联合检测对了解子痫前期病情发展、预后判断及预防子痫前期并发DIC具有重要的临床指导意义。
Objective To investigate the relationship between D-dimer (DD), homocysteine (Hcy) and high-sensitivity CRP (hs-CRP) and preeclampsia (Preeclampsia , PE) with Disseminated Intravascular Coagulation (DIC). Methods A total of 107 preeclampsia patients (PE group) were enrolled. Among them, 31 were patients with severe preeclampsia complicated with DIC (DIC group), 39 were patients with severe preeclampsia (severe PE group), 37 were mild preeclampsia D-dimer, Hcy and hs-CRP were detected in 110 patients with normal pregnancy (mild PE group) and normal pregnant women as controls. The results were analyzed and compared with SPSS 19.0 software. Results Compared with the control group, the differences of D-dimer, Hcy and hs-CRP between the DIC group and the severe PE group and between the mild PE group and the mild PE group were statistically significant P <0.01). There was a positive correlation between D-dimer and Hcy and hs-CRP in PE group and DIC group (r = 0.758,0.795, P <0.01) (r = 0.839,0.822, P <0.01) And hs-CRP concentration and PE severity was positively correlated (r = 0.481,0.731,0.548, P <0.01). Conclusions D-dimer, Hcy and hs-CRP are closely related to vascular endothelial injury in preeclampsia patients. The combined detection of D-dimer, Hcy and hs-CRP has important clinical significance in understanding the development of preeclampsia, prognosis and preventing DIC complicated by DIC Guiding significance.