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目的利用功能磁共振成像技术研究肝硬化病人静息态脑网络是否存在异常改变。方法14例肝硬化病人和14例正常对照者参加了本研究。汉字Stroop任务作为靶刺激任务,对照任务为“+”。采用组块式设计,回波平面成像血氧水平依赖的fM-RI序列采集原始数据,采用SPM99软件中的组分析方法(对照状态减去任务状态)进行统计学处理。结果肝硬化病人的静息态脑网络不同于正常对照组,执行不一致的认字任务时,扣带回后部皮层、楔前叶未见激活,而执行颜色命名任务时,静息态的默认脑功能区激活明显增加。结论扣带回后部皮层和楔前叶是肝硬化病人脑损害的敏感部位,但不是特异的生物学标记。
Objective To investigate whether there is abnormal change of resting brain network in patients with liver cirrhosis by using functional magnetic resonance imaging. Methods Fourteen patients with cirrhosis and 14 normal controls participated in this study. Chinese Stroop task as a target to stimulate the task, the control task for “+ ”. The raw data were collected by block-based design and echo planar imaging with blood oxygen level-dependent fM-RI sequences. Statistical analysis was performed using the group analysis method (control status minus task status) in SPM99 software. Results The resting brain network of patients with cirrhosis was different from that of the normal control group. When performing inconsistent recognition tasks, the cingulate cortex did not activate in the posterior cortex and did not activate in the anterior wedge of the wedge, while the resting state default Activation of brain function increased significantly. Conclusion Cingulate cortex and wedge anterior lobe are sensitive parts of brain damage in patients with cirrhosis, but not specific biological markers.