本文报告了同一家族两人患Cushing综合征,经研究证明是由于产生过量的促肾上腺皮质激素(ACTH)所致。病例1:女,28岁,已婚,双亲无血缘关系。1971年出现全身衰弱、躯干肥胖和腹纹。体检:表现为“满月”脸,水牛背,体重85kg,高165cm,四肢肌肉萎缩,血压140/85mmHg,脉率90次/分,律齐。其他方面(包括视野)均正常。患者小剂量和大剂量的地塞米松抑制试验的结果:尿17羟皮质类固醇和17酮类固醇的基线水平升高。用小剂量的地塞米松 This article reports two people with the same family Cushing syndrome, the study proved to be due to excessive adrenocorticotropic hormone (ACTH) caused. Case 1: Female, 28 years old, married, no blood relationship between parents. In 1971 there was general weakness, trunk obesity and belly pattern. Physical examination: The performance of “full moon” face, buffalo back, weight 85kg, height 165cm, limb muscle atrophy, blood pressure 140 / 85mmHg, pulse rate 90 beats / min, law Qi. Other aspects (including vision) are normal. Results of low- and high-dose dexamethasone suppression tests in patients with elevated baseline levels of urinary 17 hydroxycorticosteroids and 17 ketosteroids. Use a small dose of dexamethasone