1临床资料患者男,43岁,包皮龟头反复出现红斑糜烂2年余。患者自幼包皮过长但能完整暴露龟头。2年前包皮系带出现小片红斑、糜烂,局部刺痒不适,在当地医院以“包皮龟头炎”诊治,经10d治疗好转,基愈停药;数天后再次出现相似症状,以相同方法治疗好转。此后,类似情况反复发生,曾前往多处医院以“单纯疱疹”、“包皮龟头炎”诊治均无改善,且病损范围渐扩大,局部皮肤肥厚伴色素脱失,包皮皱缩,暴露龟头困难。6个月前龟头不能外露,故来本科就诊。患者自发病以来,无尿频、尿急、尿痛、尿线变细、排尿困难等症状,精神、食欲、睡眠及大小便正常,既往体健,家族中无相同患者,否认冶游史。体检:一般情 1 clinical data Male patient, 43 years old, repeated glaucoma foreskin glans more than 2 years. The patient’s foreskin is too long but can fully expose the glans. 2 years ago, the foreskin lace appeared small pieces of erythema, erosion, local pruritus discomfort, in the local hospital with “foreskin balanitis ” diagnosis and treatment, after 10d treatment improved, Ji Yu withdrawal; similar symptoms again after a few days, with the same treatment Better. Since then, a similar situation occurred repeatedly, had to many hospitals to “herpes ”, “balanitis ” diagnosis and treatment were no improvement, and the lesion gradually expanded, local skin hypertrophy with pigment loss, foreskin shrinkage , Exposed glans difficult. Glans 6 months ago can not be exposed, so to undergraduate treatment. Since the onset of patients, no urinary frequency, urgency, dysuria, thinning of the urinary tract, dysuria and other symptoms, mental, appetite, sleep and normal urine, previous health, no same family members, denied the tour history. Physical examination: general situation