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目的探讨运动对初诊2型糖尿病(T2DM)患者血糖稳定性的影响。方法选取糖化血红蛋白(HbA1c)<8.5%的初诊T2DM患者(DM组,38例),在严格饮食控制的基础上予以12周的运动治疗方案;同时选取正常者作为对照组(NC组,20例)。DM组治疗前后及NC组采用动态血糖监测系统进行72 h血糖监测,以日内平均血糖波动幅度(MAGE)反映血糖波动,同时测定HbA1c,评价血糖控制稳定性。结果治疗后,DM组MAGE和HbA1c均较治疗前有了明显下降[(3.6±0.8)mmol/L和(7.0±0.9)%vs.(4.9±1.0)mmol/L和(7.8±0.8)%](P<0.05),但仍然高于NC组[(2.1±0.8)mmol/L和(4.6±0.6)%](P<0.05)。结论运动有利于稳定初诊T2DM患者的血糖。
Objective To investigate the effect of exercise on blood glucose stability in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Newly diagnosed T2DM patients (DM group, 38 cases) with HbA1c less than 8.5% were enrolled in this study. After 12 weeks of exercise therapy on the basis of strict diet control, normal subjects were selected as the control group (NC group, 20 cases ). DM group before and after treatment and NC group using dynamic glucose monitoring system for 72 h blood glucose monitoring, intraday average blood glucose fluctuation amplitude (MAGE) reflects the fluctuations of blood glucose, HbA1c at the same time, to assess the stability of glycemic control. Results After treatment, the levels of MAGE and HbA1c in DM group were significantly lower than those before treatment [(3.6 ± 0.8) mmol / L and (7.0 ± 0.9)% vs 4.9 ± 1.0 mmol / L and (7.8 ± 0.8)%, (P <0.05), but still higher than those in NC group [(2.1 ± 0.8) mmol / L and (4.6 ± 0.6)%] (P <0.05). Conclusion exercise is conducive to stable blood glucose in newly diagnosed T2DM patients.