霉菌性阴道炎是一种妇科常见病。临床虽有一些治疗的药物,但疗效不够满意。我们用我系研制的酮康唑制成阴道栓,进行了刺激性试验、体外溶出试验后用于临床,结果表明,酮康唑阴道栓是高效、低毒而安全的治疗霉菌性阴道炎的新药。 材材和方法 酮康唑 本系酮康唑研制室提供;酮康唑标准品是由进口酮康唑片提纯制得。经面积归一化法测定含量为99％以上。 内标物 N-[对溴苯基]2-胺-4-氢-5氢噻唑,由本系中西药研究室提供。 Fungal vaginitis is a gynecological common disease. Although some clinical treatment of drugs, but the effect is not satisfactory. We use the ketoconazole I developed Department of vaginal suppository, conducted an irritation test, in vitro dissolution test for clinical use, the results show that ketoconazole vaginal suppository is efficient, low toxicity and safe treatment of fungal vaginitis New medicine Materials and Methods Ketoconazole The Department of ketoconazole research room provided; Ketoconazole standard is imported ketoconazole tablets were purified. The area normalization method to determine the content of 99% or more. Internal standard N- [p-bromophenyl] 2-amine-4-hydrogen -5-thiazide, provided by the Department of Chinese and Western medicine laboratory.