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胃粘膜的肠上皮化生(下简称肠化)以老年人最多见。竹内报告用亚甲蓝染色法检查892例胃病患者,肠化阳性率随年龄增加而升高,10～19岁的阳性率为22％,50岁以上即增至70％以上。80岁以后阳性率又下降,其原因不明,可能因为患肠化的病例死亡较多。肠化由于被认为可能与胃癌的发生有关,从而受到临床上重视。近几年来,关于肠化的形态和机能研究甚多,本文就其内窥镜诊断、形态学、酶学和免疫学诸方面作一综述,进而探讨其与胃癌发生的关系。
Intestinal metaplasia of the gastric mucosa (hereinafter referred to as intestinal metaplasia) is most common in the elderly. Takeuchi reported that 892 cases of stomach patients were examined with methylene blue staining. The positive rate of intestinal metaplasia increased with age. The positive rate of 10 to 19 years old was 22%, and it was increased to more than 70% from the age of 50. After 80 years of age, the positive rate dropped again. The reason for this is unknown. It may be due to more deaths from cases of intestinal metaplasia. Since it is thought that intestinal metaplasia may be related to the occurrence of gastric cancer, it has received clinical attention. In recent years, there have been many researches on the morphology and function of intestinal metaplasia. This article reviews the aspects of endoscopic diagnosis, morphology, enzymology, and immunology, and then discusses its relationship with gastric cancer.