目的分析妊娠期肝内胆汁淤积症导致早产的原因。方法回顾性分析我院2014年1月-2017年1月间收治的114例妊娠期肝内胆汁淤积症孕产妇,对其临床资料进行统计,并结合国内外文献报道,分析妊娠期肝内胆汁淤积症导致早产的原因。结果研究期间我院产科共接收7231例分娩,其中ICP患者共114例1.6%,ICP围产儿中共有24例23.5%早产儿;产妇年龄(以35岁为分界点)、产次、皮肤是否瘙痒以及是否合并糖尿病与ICP围产儿发生早产在统计学上没有关联性,而发病时间(以孕34w为分界点)、是否合并高血压以及ICP的分度与ICP围产儿发生早产在统计学上有关联性;发病时间<孕34w、合并高血压以及重度ICP三者回归系数均为正数,且OR值大于1,这表明发病时间<孕34w、合并高血压以及重度ICP是ICP围产儿发生早产的高危因素。结论妊娠期肝内胆汁淤积症致围产儿早产的高危因素为发病时间<孕34w、合并高血压以及重度ICP,临床上若发现有此指证,应引起重视。 Objective To analyze the causes of preterm labor during intrahepatic cholestasis of pregnancy. Methods Retrospective analysis of 114 pregnant women with intrahepatic cholestasis of pregnancy admitted in our hospital from January 2014 to January 2017 retrospectively analyzed the clinical data and combined with domestic and foreign literature reports to analyze intrahepatic bile during pregnancy Sedimentosis causes premature birth. Results During the study, 7231 cases of obstetrics and gynecology were received in our hospital, including 114 cases of ICP (1.6%) and 24 cases of 23.5% of preterm infants in ICP perinatal age. The age of women (35 years old) As well as whether there was no statistical correlation between diabetes mellitus and preterm birth in perinatal ICP, but the onset time (with 34w as the cut-off point), the incidence of hypertension and ICP index and perinatal preterm birth in ICP were statistically significant Correlation; morbidity time