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研究对象包括正常对照、NPC患者及血清EB病毒相关抗体IgA/EA阳性和IgA/EA阴性而IgA/VCA阳性等NPC高危人群。NPC患者及NPC高危人群淋巴细胞BP的SCE诱发率显著高于对照。在有G6PD抑制剂DHEA存在时,这种差异进一步增大。而且,几个组间BP+DHEA的SCE诱发率均值及个体分布呈现明显的不同,这种差异与几个人群间NPC风险程度的差别相当吻合。可以认为,在区分NPC风险程度不同的人群方面,BP+DHEA SCE诱发试验可能是一个比较有效的方法,但能否作为一个检出NPC易感个体的实用指标,还有待前瞻观察的结果。
The study subjects included normal controls, NPC patients, and NPC high-risk groups with serum EBV-related antibodies IgA/EA positive and IgA/EA negative but IgA/VCA positive. The prevalence of SCE in lymphocyte BP was significantly higher in NPC patients and NPC at high risk than in controls. This difference is further increased in the presence of the G6PD inhibitor DHEA. Furthermore, the mean and individual distribution of SCE in BP+DHEA between groups was significantly different, and this difference was quite consistent with the difference in NPC risk among several populations. It can be considered that BP + DHEA SCE induction test may be a more effective method in differentiating people with different risk levels of NPC, but whether it can be used as a practical indicator to detect NPC-susceptible individuals has yet to be prospectively observed.