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目的探讨乙肝免疫球蛋白阻断母婴传播的效果。方法实验组120例孕妇孕28周起注射乙肝免疫球蛋白(HBIG)200Iu控制,每4周1次,共3次,对照组80例未注射。结果实验组HB-sAg阳性孕妇分娩的新生儿HBsAg(+)率96.67%,明显高于对照组67.5%,差异有统计学意义(P<0.001)。抗HBs(+)率为51.67%,与对照组(12.5%)相比差异有统计学意义(P<0.001)。结论乙肝免疫球蛋白阻断母婴乙型肝炎病毒的传播具有显著效果。
Objective To investigate the effect of hepatitis B immunoglobulin in blocking mother-to-infant transmission. Methods In the experimental group, 120 pregnant women were injected HBI 200Iu at 28 weeks’ gestation, once every 4 weeks for 3 times. In the control group, 80 cases were not injected. Results HBsAg (+) rate of 96.67% of neonates born to HBsAg-positive pregnant women in experimental group was significantly higher than that of control group (67.5%), the difference was statistically significant (P <0.001). The anti-HBs (+) rate was 51.67%, which was significantly different from that of the control group (12.5%) (P <0.001). Conclusion Hepatitis B immunoglobulin has a significant effect in blocking the transmission of hepatitis B virus (HBV).