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目的观察帕罗西汀治疗功能性消化不良(FD)伴焦虑、抑郁障碍的临床疗效。方法将80例功能性消化不良伴焦虑、抑郁障碍患者随机分为两组,观察组40例,常规治疗基础上联合帕罗西汀;对照组40例,仅给予常规治疗。观察期均为4周,观察治疗前与治疗4周末FD症状评分、Zung抑郁自评量表(SDS)评分及焦虑自评量表(SAS)评分的变化,并进行对比分析。结果治疗4周末,观察组SAS评分(40.37±5.54)比治疗前评分(55.88±4.32)低,也比对照组(56.75±5.57)低,差异有统计学意义(P<0.01);观察组SDS评分(41.83±5.43)比治疗前评分(55.76±4.61)低,也比对照组(57.04±4.92)低,差异有统计学意义(P<0.01)。而对照组治疗前后SAS、SDS评分差异无统计学意(P>0.05)。两组疗效比较:观察组显效22例,有效15例,无效3例,总有效率为92.5%,比对照组(总有效率为70.0%)高,两组差异有统计学意义(2χ=8.407,P<0.05)。结论常规治疗基础上联合帕罗西汀,既能显著改善FD症状,又能有效控制功能性消化不良患者的焦虑、抑郁障碍,疗效优于常规治疗。
Objective To observe the clinical efficacy of paroxetine in the treatment of functional dyspepsia (FD) with anxiety and depression. Methods Eighty patients with functional dyspepsia and anxiety and depression were randomly divided into two groups. The observation group was 40 cases. Paroxetine was given on the basis of conventional treatment. The control group was given only conventional treatment. The observation period was 4 weeks. The changes of FD symptom score, Zung depression self-rating scale (SDS) and anxiety self-rating scale (SAS) scores before and after 4 weeks of treatment were observed and compared. Results At the end of 4 weeks of treatment, the SAS score of the observation group (40.37 ± 5.54) was lower than that of the control group (55.88 ± 4.32) and lower than that of the control group (56.75 ± 5.57) (P <0.01) The score (41.83 ± 5.43) was lower than that before treatment (55.76 ± 4.61), which was also lower than that of the control group (57.04 ± 4.92) (P <0.01). The SAS and SDS scores of the control group before and after treatment had no statistical significance (P> 0.05). The curative effect comparison of two groups: The observation group was effective in 22 cases, effective in 15 cases, ineffective in 3 cases, the total effective rate was 92.5%, higher than the control group (total effective rate was 70.0%), the difference between the two groups was statistically significant (2χ = 8.407 , P <0.05). Conclusion The combination of paroxetine and conventional paroxetine can not only significantly improve the symptoms of FD but also effectively control the anxiety and depression of patients with functional dyspepsia. The curative effect is superior to conventional treatment.