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作者在实验研究的基础上，选择了临床资料相近的心脏瓣膜病患者２０例，根据术中使用心脏停搏液不同，随机分为２组：①冷氧合血间歇灌注组（ｎ＝１０）；②持续温血停搏液组（ｎ＝１０）．观察了心肌能量代谢变化及血浆磷酸肌酸激酶同工酶（ＣＰＫ－ＭＢ）的改变；同时亦进行了临床资料观察．结果：①冷血组ＣＰＫ－ＭＢ变化于手术结束后开始明显升高，术后１８ｈ达高峰。温血组术后各期酶学指标与冷血组相比均明显降低（Ｐ＜０．０１）．②心肌能量代谢变化：冷血组缺血未ＡＴＰ，总腺苷酸（ＡＮ）含量及ＡＴＰ／ＡＤＰ比值分别下降至停搏前的０．５０±０．１８；０．５８±０．１６和０．５９±０．１８，明显低于温血组的０．８７±０．２３；０．９２±０．１９和０．８６±０．２２．③临床资料观察：温血组的自动复跳率及术后血管活性药物使用率优于冷血组，结论：持续灌注温血停搏技术可以充分保证心肌在常温停跳时的氧供，保存和增加心肌能量的储备，避免了心肌缺血缺氧期，是一种理想的心肌保护法．
On the basis of experimental study, 20 patients with valvular heart disease with similar clinical data were selected and randomly divided into 2 groups according to the intraoperative cardioplegic solution: ① intermittent cold oxygenated blood perfusion group (n = 10) ; ② continuous warm blood cardioplegia group (n = 10). Changes in myocardial energy metabolism and changes in plasma creatine kinase (CPK-MB) were observed. Clinical data were also observed. Results: ①The changes of CPK-MB in cold-blooded group began to increase significantly after operation, reaching the peak at 18 hours after operation. Compared with the cold-blooded group, the enzymological indexes of warm-blooded group were significantly decreased (P <0.01). ② The changes of myocardial energy metabolism: The content of ATP, total adenosine acid (AN) and ATP / ADP in cold-blooded group decreased to 0.50 ± 0.18, 0.58 ± 0.16 and 0 .59 ± 0.18, which was significantly lower than that of the warm-blooded group (0.87 ± 0.23; 0.92 ± 0.19 and 0.86 ± 0.22). ③ Clinical data observation: The rate of spontaneous rebound in warm-blooded group and the rate of postoperative vasoactive drug use is superior to cold-blooded group. Conclusion: Continuous perfusion warm-blooded arrest technique can fully guarantee oxygen supply, preservation and Increase myocardial energy reserve, to avoid myocardial ischemia and hypoxia, is an ideal method of myocardial protection.