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目的:评价急性髓细胞性白血病中核型在预后评估中的意义。方法:回顾性分析102例初发急性髓细胞性白血病(非APL),按核型将其分为低危、中危、高危和未分类4组,评价核型在预后评估中的意义。结果:核型低危组、中危组和高危组的完全缓解率依次为76%、63%和55%,差异有显著性(P=0.0000294);低危组、中危组的总生存时间显著高于高危组(P值分别为0.0454和0.0421),3组的无病生存时间和2年生存率差异无显著性(P>0.05)。结论:急性髓细胞性白血病的细胞遗传学与预后具有相关性。
Objective: To evaluate the significance of karyotypes in the prognosis of acute myeloid leukemia. Methods: A retrospective analysis of 102 cases of newly diagnosed acute myelogenous leukemia (non-APL), according to the karyotypes were divided into low, medium, high risk and not classified 4 groups, evaluation of karyotype significance in prognosis evaluation. Results: The complete remission rates of karyotype low-risk group, middle-risk group and high-risk group were 76%, 63% and 55%, respectively, with significant difference (P = 0.0000294) (P = 0.0454 and 0.0421, respectively). There was no significant difference in disease-free survival time and 2-year survival rate between the three groups (P> 0.05). Conclusions: The cytogenetics of acute myeloid leukemia is associated with prognosis.