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母-胎免疫耐受一直是免疫学界研究的热点,大部分研究者认为母亲对胎儿所携带的父系的抗原产生耐受是通过母-胎界面处占优势的Th2型细胞因子的免疫抑制作用。越来越多的研究证明,自然杀伤T(NKT)细胞参与了母-胎界面处对Th1和Th2型细胞因子平衡的调节。现围绕NKT细胞在母-胎界面处的免疫调节功能,对NKT细胞的特性、分类,以及NKT细胞与正常妊娠和流产之间的关系等方面做一综述。
Maternal-fetal immune tolerance has been a hot topic in immunology research. Most researchers believe that the mother’s tolerance to the antigens of the fetus carried by the fetus is the immunosuppressive effect of Th2-type cytokines predominated at the maternal-fetal interface. More and more studies have demonstrated that natural killer T (NKT) cells are involved in the regulation of Th1 and Th2 cytokine balance at the maternal-fetal interface. Now around the NKT cells at the maternal-fetal interface immunomodulatory function of NKT cell characteristics, classification, as well as NKT cells and normal pregnancy and abortion, the relationship between the make a review.