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桂枝汤可拮抗新斯的明性胃肠功能亢进大鼠的胃窦、十二指肠和空肠生长抑素含量的降低，也可使阿托品性胃肠功能受抑大鼠的生长抑素含量降低，并使之趋向正常；下丘脑和血液中的生长抑素含量变化则与之相反；对正常大鼠却无明显的影响。提示本方对胃肠运动机能的双向调节机理之一可能是通过调节中枢下丘脑、血液、胃肠局部组织中的生长抑素含量而发挥作用
Guizhi decoction can antagonize neostigated gastrointestinal hyperthyroidism rats gastric antrum, duodenum and jejunum somatostatin content decreased, but also make atropine gastrointestinal suppression of rats somatostatin content Reduce, and make it tend to normal; hypothalamus and blood somatostatin content changes in the opposite; but no significant effect on normal rats. It is suggested that one of the mechanisms of bidirectional regulation of gastrointestinal motility may be through the regulation of somatostatin content in the central hypothalamus, blood and gastrointestinal tissues