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解剖标本用甲醛水溶液作防腐剂已有悠久历史。虽然甲醛防腐效果较好,但由于刺激性大,有一定毒性,大量摄入或长期接触可导致急、慢性中毒(包括甲醛溶液中所含甲醇的毒性);此外,如保存不当,标本仍可为某些真菌所污染。因此有必要寻找一种新的安全可靠的防霉剂。国外曾用异噻唑酮(Isothiazolone)及其衍生物作动物浸液的防霉剂,但能否用于解剖标本防霉未见报导,为了探讨这方面的可能性,我们选用抗菌谱广、抑菌浓度低,且水及脂溶性好而无挥发性的异噻唑酮和广谱抗真菌药益康唑进行一年实验观察,取得一定效果,现报导如下: 一、材料 1.菌种:从本校解剖教研室尸体标本上的霉菌分离所得,由广东省微生物研究所鉴定为曲霉属黄曲霉菌(Aspergillus flavus Link)经
Anatomical specimens with aqueous formaldehyde as a preservative have a long history. Although formaldehyde preservative effect is good, but due to irritating large, a certain toxicity, a large number of intake or long-term exposure can lead to acute and chronic poisoning (including the formaldehyde solution containing methanol toxicity); In addition, if not properly preserved, the specimen can still Contaminated by some fungi. Therefore, it is necessary to find a new safe and reliable antifungal agent. Abroad has used isothiazolone (Isothiazolone) and its derivatives as anti-mildew agent for animal immersion, but can be used for anatomy specimens mildew has not been reported, in order to explore the possibility of this aspect, we choose broad antibacterial spectrum, inhibition Bacterial concentration is low, and the water and fat-soluble volatile non-isothiazolone and broad-spectrum antifungal econazole for one year experimental observation, and achieved certain results are reported as follows: First, the material 1 strains: from Mycological department of the school autopsy specimens isolated from the mold, the Guangdong Institute of Microbiology identified Aspergillus flavus Aspergillus (Aspergillus flavus Link) by