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1976～1982年,苏州吴县制药厂在中国科学院上海生物化学研究所、苏州市第四人民医院、苏州医学院药理学教研组等单位的密切配合下,采取反复盐析、结晶、柱层析等工业生产工序,首次从我国丰富的猪胰资源中成功地提取了结晶糜胰蛋白酶、口服用糜胰蛋白酶、外用糜胰蛋白酶、糜蛋白酶、胰蛋白酶等五个原料品种,并将其制成了相应的制剂(江苏省卫生厅药政局均已批准),现概括介绍如下:(一)技术路线:
1976 ~ 1982, Suzhou Wuxian Pharmaceutical Factory in Shanghai Institute of Biochemistry, Chinese Academy of Sciences, the Fourth People’s Hospital of Suzhou City, Suzhou Medical College Pharmacology Teaching and Research Unit and other units in close cooperation to take repeated salting, crystallization, column chromatography and other industries Production process, for the first time from our rich porcine pancreatic resources successfully extracted the crystallization of trypsin, oral use of trypsin, topical trypsin, chymotrypsin, trypsin and other five varieties of raw materials, and made of the corresponding (Jiangsu Provincial Department of Health Pharmaceutical Administration have approved), are summarized as follows: (a) the technical route: