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目的观察胃祺II号方治疗功能性消化不良(FD)的临床疗效和对大鼠胃排空的影响。方法收集FD患者68例,随机分为治疗组(37例)和西沙比利对照组(31例),观察其临床疗效;同时观察该方对人鼠酚红胃排空的影响.结果胃祺Ⅱ号方和西沙必利的总有效率分别为89.19％和83.87％,无统计学差异(P<0.05);本方能改善FD各主要临床症状,且无不良反应;随访中药组无一例复发,显著优于西药组(复发率33.33％)(P<0.05).该方能促进大鼠胃酚红排空,较对照组有显著差异(P<0.05).结论胃祺II号方能有效改善FD各主要症状,近期疗效显著,远期疗效可靠,且无不良反应.该方能显著促进胃排空,改善胃运动功能。
Objective To observe the clinical curative effect of Weiwei II on functional dyspepsia (FD) and its effect on gastric emptying in rats. Methods Sixty-eight patients with FD were randomly divided into treatment group (37 cases) and cisapride control group (31 cases). The clinical efficacy was observed. At the same time, the effect of this prescription on gastric emptying of human phenol red was observed. The total effective rates of No. 2 and cisapride were 89.19% and 83.87%, respectively, with no statistical difference (P<0.05); this party could improve the main clinical symptoms of FD without adverse reactions; there was no relapse in the follow-up Chinese medicine group. Significantly better than western medicine group (recurrence rate 33.33%) (P<0.05). This can promote gastric emptying of rat phenol red, compared with the control group, there is significant difference (P<0.05). Conclusion Stomach fistula II can effectively Improve the main symptoms of FD, the recent significant effect, reliable long-term efficacy, and no adverse reactions. This can significantly promote gastric emptying and improve gastric motility.