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次生代谢产物是植物在其生长发育和对环境的适应过程中形成的,通常是药用植物中的主要活性成分,药材品质的物质基础。但次生代谢产物的生源途径复杂,其产生和积累受到自身遗传和环境中各种生物和非生物因素的调控,影响了药用植物作为药材的品质控制及其活性成分的开发利用。系统生物学思维与方法是系统全面探索生物的有力工具,随着现代分子生物学技术及生物信息学的发展,系统整合基因组、转录组、蛋白组和代谢组等组学技术,将为药用植物次生代谢产物研究带来新的机遇。这种整体、系统的研究方法在药用植物次生代谢产物形成的生物合成途径、信号转导、生态环境及其代谢工程等研究中的应用,构建次生代谢物生物合成基因表达调控系统模型,对于系统阐释药用植物有效成分成因和道地药材形成机制、代谢工程产生药用植物活性成分、和药用植物资源合理开发利用等具有重要意义。
Secondary metabolites are formed by plants during their growth and adaptation to the environment, and are usually the material basis for the quality of medicinal herbs, the major active ingredient in medicinal plants. However, secondary metabolites are complicated in origin and their production and accumulation are controlled by various biological and non-biological factors in their own inheritance and environment, affecting the quality control of medicinal plants as medicinal materials and the development and utilization of their active ingredients. Systematic biological thinking and methods are powerful tools for systematic and comprehensive exploration of biology. With the development of modern molecular biology techniques and bioinformatics, systematical integration of genomics, transcriptome, proteome and metabolomics will be of medicinal Plant secondary metabolites research brings new opportunities. This holistic and systematic research method is applied to the biosynthetic pathway, signal transduction, ecological environment and metabolic engineering of secondary metabolites of medicinal plants, and the construction of secondary metabolite biosynthesis gene expression regulatory system model , Which is of great significance for systematically explaining the causes of medicinal plant active ingredients and the formation mechanism of medicinal plants, the active ingredients of medicinal plants produced by metabolic engineering, and the rational exploitation and utilization of medicinal plant resources.