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目的 :研究人乳头状瘤病毒 (HPV)型别对小儿喉乳头状瘤 (JLP)预后的影响。方法 :应用聚合酶链反应结合斑点杂交技术对 2 5例JLP的石蜡标本进行HPV定型分析 ,并统计HPV11、HPV6 感染组的气管切开率和术后复发率。结果 :HPV总检出率为 96.0 % ,其中HPV11为 5 6.0 % ,HPV6 为 4 0 .0 % ,HPV16、18、33无一例阳性。HPV11感染组的气管切开率为 71.4 % ,术后复发率为 85 .7% ;HPV6 感染组的气管切开率为 3 0 .0 % ,术后复发率为4 0 .0 %。两组分别比较 ,其差异均有显著性意义 (P <0 .0 5 )。结论 :HPV6、11与JLP发生密切相关 ,HPV11感染与JLP的喉梗阻和术后复发率相关 ,HPV11感染可作为JLP预后评判的重要依据。
Objective: To study the effect of human papillomavirus (HPV) type on the prognosis of children with laryngeal papilloma (JLP). Methods: Polymerase chain reaction (PCR) combined with dot blot hybridization was performed on 25 cases of JLP paraffin specimens. The tracheotomy rate and postoperative recurrence rate of HPV11 and HPV6 infection groups were calculated. Results: The total detection rate of HPV was 96.0%, among which HPV11 was 5 6.0%, HPV6 was 40.0%, and HPV16,18,33 was not positive. The tracheotomy rate of HPV11 infection group was 71.4% and the recurrence rate was 85.7%. The tracheotomy rate of HPV6 infection group was 30.0% and the recurrence rate was 40.0%. The differences between the two groups were significant (P <0.05). Conclusion: HPV6, 11 is closely related to JLP. HPV11 infection is associated with laryngeal obstruction and recurrence rate of JLP. HPV11 infection may be used as an important basis for judging JLP prognosis.