心肌肥厚是高血压病常见的并发症,是心血管疾病的独立危险因素。心脏肥厚包括细胞和细胞外基质的增多。除压力超负荷的机械刺激外,神经体液因子及血管活性物质在致心肌肥厚过程中起重要作用。虽然血管活性肽最先被发现是因为它们对血流动力学的作用,但是越来越多的证据显示血管 Cardiac hypertrophy is a common complication of hypertension and is an independent risk factor for cardiovascular disease. Cardiac hypertrophy includes increased cellular and extracellular matrix. In addition to pressure overload mechanical stimulation, neurohumoral factors and vasoactive substances play an important role in the process of cardiac hypertrophy. Although vasoactive peptides were first discovered because of their hemodynamic effects, there is growing evidence that blood vessels