目的:评价赛乐特治疗肠易激综合征的效果和依从性,探讨其可能的作用机制。方法:67例肠易缴综合征患者被随机分为赛乐特治疗组(n=32)和多虑平治疗组(n=35)。应用赛乐特片10～30mg,早餐时顿服,多虑平片25～50mg/次,3次/d口服,疗程8周,分别于治疗后第6、12周末记录腹痛、腹泻、便秘和肠外症状改善情况并评分。结果:短期内缓解腹痛和腹泻,赛乐特优于多虑平(P<0.05);缓解便秘,赛乐特明显优于多虑平(P<0.01);应用赛乐特的依从性优于多虑平(P<0.01)。结论:治疗肠易激综合征,赛乐特优于多虑平。 Objective: To evaluate the effect and compliance of serotonergic treatment of irritable bowel syndrome and to explore its possible mechanism. Methods: Sixty-seven patients with predominantly symptomatic Syndrome were randomized to treatment with methotrexate (n = 32) and doxepin (n = 35). Application of race tablets 10 ~ 30mg, breakfast Dayton clothing, doxepine 25 ~ 50mg tablets / times, 3 times / d oral treatment for 8 weeks, respectively, at the 6th and 12th week after treatment recorded abdominal pain, diarrhea, constipation and Improve the parenteral symptoms and score. Results: In the short term, abdominal pain and diarrhea were relieved, and racetrap was superior to doxepin (P <0.05); constipation and salmeterol were superior to doxepin (P <0.01) Doxepin (P <0.01). Conclusion: The treatment of irritable bowel syndrome, 赛 Late better than doxepin.