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泛酸的生理,病理生理和药理作用虽已经深入研究过,但其在射线生物学过程中的作用则研究得很少,作者用200只同一种系的两性小白鼠,体重25—30克,每50只一组,分为四组进行了研究,第Ⅰ组不用泛酸处理的整体照射组(对照组),第Ⅱ组用泛酸处理一星期,休息一星期用X射线照射。第Ⅲ组用泛酸处理一星期后立即用X射线照射,第Ⅳ组照射后立即用泛酸处理一星期,皮下注射七天泛酸,每天剂量达0.5mg泛酸钙,照射条件,500仑,滤片0.5毫米铜,180千伏,焦距50厘米,记录卅天四组存活动物数,并作出曲线。实验结果表明:第Ⅱ组存活动物最多,21天存活一半(S_(50)=21)对照组在第八天存活50％(S_(50)=71),平均寿命延长相当于200％,第Ⅲ组死亡率近似于对照组,平均寿命延
Although the physiological, pathophysiological and pharmacological effects of pantothenic acid have been studied in depth, its role in radiobiological processes has been studied very rarely. The author used 200 bisexual mice of the same strain and weighed 25-30 grams each. Groups of 50 rats were divided into four groups. Group I was treated with pantothenic acid in the whole irradiation group (control group). Group II was treated with pantothenic acid for one week and rested for one week with X-ray irradiation. Group III was treated with X-rays immediately after treatment with pantothenic acid for one week. Group IV was immediately treated with pantothenic acid for one week and subcutaneously injected with pantothenic acid for seven days. The daily dose was 0.5 mg of calcium pantothenate, irradiation conditions, 500 lun, filter 0.5 mm. Copper, 180 kV, focal length 50 cm, recorded the number of surviving animals in the four groups and made a curve. The experimental results showed that the survival of animals in Group II was the highest, and half of 21-day survivors (S_(50) = 21) in the control group survived 50% on the eighth day (S_(50)=71), and the average life span was equal to 200%. Mortality in Group III is similar to that in the control group, with an average life expectancy