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目的:探讨2型糖尿病(T2DM)患者微量白蛋白尿与代谢综合征(MS)的相关性。方法:282例T2DM患者根据是否合并MS分为MS组(163例)和非MS组(119例),测定24h尿白蛋白(UAlb)及相关生化指标,比较两组UAlb水平及糖尿病肾病(DN)患病率,采用多元Logistic回归方法分析T2DM患者微量白蛋白尿的危险因素。结果:MS组的UAlb及DN患病率明显高于非MS组,且随着MS组分增加,UAlb水平显著升高。多元Logistic回归分析表明甘油三酯、糖化血红蛋白、收缩压为影响UAlb的独立危险因素。结论:T2DM患者微量白蛋白尿与MS密切相关,需采取综合干预措施避免或延缓DN的发生发展。
Objective: To investigate the correlation between microalbuminuria and metabolic syndrome (MS) in type 2 diabetes mellitus (T2DM). Methods: 282 cases of T2DM patients were divided into MS group (163 cases) and non-MS group (119 cases) according to whether MS was combined or not, 24-hour urinary albumin (UAlb) and related biochemical indexes were measured. UAb levels and diabetic nephropathy ) Prevalence, using multivariate logistic regression analysis of risk factors for microalbuminuria in T2DM patients. Results: The prevalence of UAlb and DN in MS group was significantly higher than that in non-MS group, and the level of UAlb was significantly increased with the increase of MS fraction. Multivariate Logistic regression analysis showed that triglycerides, glycosylated hemoglobin and systolic blood pressure were independent risk factors influencing UAlb. Conclusion: Microalbuminuria in patients with T2DM is closely related to MS, and comprehensive interventions are needed to avoid or delay the occurrence and development of DN.