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本文研究了慢性氟中毒大鼠对外源性放射性碘标记催乳素由循环血中的清除速率及其在卵巢和子宫的结合。结果表明:(1)静脉一次性注入放射性~(125)I标记催乳素后10、30、60min慢性氟中毒组和对照组大鼠血浆中残留的总放射及可被特异性抗血清沉淀的放射性基本相同;(2)静脉一次性注入放射性~(125)I标记催乳素后60min慢性氟中毒和对照组大鼠卵巢和子宫的放射性基本相同。这些结果提示慢性氟中毒大鼠催乳素由循环血中的代谢清除率与对照组基本相同。这为慢性氟中毒大鼠血浆中催乳素水平降低的主要机制是垂体激素释放障碍的观点提供了依据。
In this paper, chronic fluorosis in rats on the exogenous radioactive iodine labeled prolactin by circulating blood clearance rate and its binding in the ovary and the uterus. The results showed that: (1) The total radioactivity in the plasma of rats in the chronic fluorosis group and the control group at 10, 30 and 60 minutes after intravenous injection of radioactive 125 I-labeled prolactin and radioactivity that could be precipitated by specific antisera (2) 60 minutes after intravenous injection of radioactive (125) I labeled prolactin, the radioactivity in ovary and uterus of rats in control group was almost the same. These results suggest that the clearance rate of prolactin in circulating fluorosis rats is basically the same as the control group. This provides a basis for the hypothesis that the main mechanism of the decrease of prolactin level in plasma of rats with chronic fluorosis is pituitary hormone release disorder.