核因子(NF)-κB是属于Rel家族的转录因子,是与诸多包括动脉粥样硬化(AS)在内炎症性疾病密切相关的细胞内信号转导通路。在AS发展的各个阶段,从斑块形成到稳定和破裂,活化的NF-κB通过调节下游如细胞因子、炎症介质、趋化因子等参与AS的信号转导。1 NF-κB通路的组成1.1 NF-κB家族转录因子NF-κB是1986年首次在成熟的B淋巴细胞核提取时发现的,能与免疫球蛋白kappa(k)轻链上的 Nuclear factor (NF) -κB is a transcription factor belonging to the Rel family and is an intracellular signal transduction pathway that is closely associated with many inflammatory diseases including atherosclerosis (AS). At various stages of AS development, from plaque formation to stabilization and rupture, activated NF-κB is involved in signal transduction of AS by regulating downstream factors such as cytokines, inflammatory mediators, chemokines and the like. 1 NF-κB pathway 1.1 NF-κB family of transcription factors NF-κB was first found in 1986 when the mature B lymphocyte nuclear extract, with immunoglobulin kappa (k) light chain