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疫苗产生的抗感染效果对HBV携带状态和相关的慢性肝病的预防很重要,检测疫苗诱导的抗体水平可以决定是否需要加强接种。作者对一组在新生儿期接种乙型肝炎疫苗的儿童进行了为期7年的HBV标志物连续检测,以评价疫苗接种后抗-HBs对HBV感染及携带状态具保护水平的指标。 研究包括对1041名新生儿母亲的血清HBV抗体检测。新生儿均于出生后8周、16周、9个月时分别接受10μg的血源疫苗,在1、2、3、4、5和7岁时分别取指血检测HBsAg、抗-HBc、抗-HBs及HBeAg。以抗-HBs水平
The anti-infective effect produced by the vaccine is important for the prevention of HBV carrier status and associated chronic liver disease, and the level of antibody induced by the vaccine can determine whether vaccination is required. The authors conducted a seven-year continuous series of HBV markers in a group of children vaccinated against hepatitis B during the neonatal period to assess the level of protection against HBV infection and carriage by anti-HBs following vaccination. The study included a serum HBV antibody test on 1,041 newborn mothers. Neonates received 10μg of blood-borne vaccine respectively at 8 weeks, 16 weeks and 9 months after birth. At 1, 2, 3, 4, 5 and 7 years old, blood tests were performed to detect HBsAg, anti-HBc, -HBs and HBeAg. Anti-HBs levels