急性肝功能衰竭(ALF)患者由于脑血管扩张而脑血流自我调节丧失。已知动脉低碳酸血症可致脑血管收缩,因而,研究旨在了解是否可通过机械性过度通气重建脑血流自我调节。 方法:相继7例ALF且属肝性脑病Ⅳ期的患者,予维持机械通气,并行桡动脉插管以采集血样、监测平均动脉压(MAP)。输注去甲肾上 Patients with acute liver failure (ALF) lose cerebral blood flow self-regulation due to cerebrovascular dilatation. Arterial hypocapnia is known to cause cerebral vasoconstriction and therefore the study aimed to understand whether cerebral blood flow self-regulation could be reconstructed by mechanical hyperventilation. Methods: Seven patients with ALF and stage Ⅳ hepatic encephalopathy were treated with mechanical ventilation and radial artery catheterization to collect blood samples for monitoring mean arterial pressure (MAP). Infusion to the kidney