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[目的]探讨血清超敏C反应蛋白(hs-CRP)和IL-6检测在2型糖尿病及其血管并发症中的临床价值。[方法]采用散射免疫比浊法检测38例单纯2型糖尿病患者及33例2型糖尿病合并下肢血管病变患者血清hs-CRP,同时用Elisa法检测IL-6,并与对照组比较。[结果]2型糖尿病患者及2型糖尿病合并下肢血管病变患者血清hs-CRP和IL-6显著高于对照组(P﹤0.01),2型糖尿病合并下肢血管病变患者血清hs-CRP和IL-6显著高于单纯2型糖尿病患者(P﹤0.01)。[结论]炎症机制在2型糖尿病并发下肢血管病变时发挥了重要的作用,hs-CRP和IL-6在预测糖尿病并发下肢血管病变中具有重要的临床意义。
[Objective] To investigate the clinical value of serum hs-CRP and IL-6 in type 2 diabetes mellitus and its vascular complications. [Method] The serum hs-CRP levels in 38 patients with simple type 2 diabetes mellitus and 33 patients with type 2 diabetes mellitus and those with lower extremity vascular lesions were measured by the method of nephelometry. Meanwhile, IL-6 was detected by Elisa method and compared with the control group. [Results] The serum hs-CRP and IL-6 levels in patients with type 2 diabetes mellitus and type 2 diabetes mellitus with lower extremity vascular disease were significantly higher than those in control group (P <0.01). The serum hs-CRP and IL- 6 was significantly higher than that of type 2 diabetic patients (P <0.01). [Conclusion] Inflammatory mechanism plays an important role in the pathogenesis of lower extremity vascular disease in type 2 diabetes. The hs-CRP and IL-6 have important clinical significance in the prediction of diabetic lower extremity vascular disease.