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目的：探讨甲基强的松龙治疗多发性硬化（MS）的副作用。方法：将54例患者随机分为观察组22例和对照组32例，观察组鞘内缓慢注射甲基强的松龙，对照组采用静脉缓慢滴注甲基强的松龙，比较两组不良反应的发生情况。结果：观察组副作用发生率50％，对照组副作用发生率100％。结论：糖皮质激素作为 MS的主要治疗用药，治疗方法无论从鞘内注射还是静脉滴注，其副作用通常都较高，病情观察与护理就显得尤为重要。“,”Objective To explore methylprednisolone in the treatment of multiple sclerosis (MS) side effects .Methods 54 patients were ran-domly divided into the observation group 22 cases and control group 32 cases ,observation of intrathecal injection of methyl prednisolone group gradually strong ,the control group using slow intravenous methylprednisolone infusion of methylprednisolone ,occurrence of adverse reactions of two groups of .Results in the observation group ,the incidence of side effect was 50% ,the control group the incidence of side effect was 100% . Conclusion glucocorticoid as primary therapy for MS treatment ,treatment method in terms of intrathecal injection or intravenous drip ,its side effects are usually higher ,observation and nursing is very important .