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目的 研究胎儿宫内生长迟缓 (IUGR)患者胎盘表皮生长因子受体 (EGFR)的表达与正常妊娠及巨大儿胎盘之间是否有差异 ,并分析其变化与胎盘绒毛发育是否有关。方法 取足月分娩胎盘组织标本 6 3例 ,于分娩后立即置于 4%中性甲醛缓冲液固定。用免疫组织化学SP法进行胎盘EGFR检测。同时对末梢绒毛血管大小、面积及绒毛面密度等进行分析测量。结果 IUGR组胎盘EGFR的表达较正常对照组和巨大儿组明显增加 (P <0 0 1) ,IUGR胎盘末梢绒毛血管数及血管占绒毛横面积比均明显减少 (P均 <0 0 5 ;P均 <0 0 0 1) ;而巨大儿组与对照组比较无显著性差异。三组胎盘绒毛面密度无显著性差异 (P >0 0 5 )。结论 IUGR儿胎盘EGFR表达增加与其胎盘绒毛发育不良有关 ,EGFR在胎儿胎盘的生长发育及IUGR的发生中起重要调节作用。
Objective To investigate whether placental epidermal growth factor receptor (EGFR) expression is correlated with normal pregnancy and macrophage placenta in patients with intrauterine growth retardation (IUGR), and to analyze whether there is a relationship between the expression of EGFR and placental villus development. Methods Totally 63 placenta tissue samples of full-term delivery were placed in 4% neutral formalin buffer immediately after delivery. Placental EGFR detection was performed by immunohistochemical SP method. At the same time on the villus vascular size, area and villi surface density analysis and measurement. Results The expression of EGFR in placenta of IUGR group was significantly higher than that of normal control group and macrosomia group (P <0.01). The numbers of placental villi and villus area were significantly decreased in IUGR group (all P <0 05; P All <0 0 0 1). However, there was no significant difference between the macrosomia group and the control group. Three groups of placenta surface density no significant difference (P> 0 05). Conclusion The increase of EGFR expression in placenta of IUGR is related to the dysplasia of placenta. EGFR plays an important role in the growth and development of fetal placenta and the occurrence of IUGR.