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人尿激肽酶原是从男性尿液中提取的糖蛋白,为组织型激肽酶原。有研究发现其有缩小急性脑梗死患者梗死面积、改善神经功能的作用,机制可能与选择性扩张缺血区微动脉,改善缺血脑组织微循环有关[1]。另有研究表明金属基质蛋白酶(MMPs)存在脑缺血后的表达变化,并与侧枝循环重建、血脑屏障结构的完整性、血流动力学等病理及病理生理过程相关[2,3]。提示人尿激肽原参与脑缺血损伤与修复的过程可能与MMPs有关,但相关研究较少。本
Human urokinase is a glycoprotein extracted from male urine and is a tissue-type kininogen. Some studies have found that it can reduce infarct size and improve neurological function in patients with acute cerebral infarction. The mechanism may be related to the selective expansion of ischemic regional arterioles and the improvement of microcirculation of ischemic brain tissue [1]. Other studies have shown that matrix metalloproteinases (MMPs) have the expression changes after cerebral ischemia, and are related to collateral circulation reconstruction, the integrity of blood-brain barrier structure, hemodynamics and other pathological and pathophysiological processes [2,3]. Prompted that human pro-Kintrogen involved in cerebral ischemic injury and repair process may be related to MMPs, but less relevant research. this