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目的探讨宫颈癌患者血管内皮生长因子(VEGF)及其微血管密度(MVD)的表达与肿瘤侵袭转移的关系。方法采用免疫组织化学方法检测52例慢性宫颈炎组织及60例宫颈癌组织VEGF及MVD的表达情况。结果宫颈癌组织及慢性宫颈炎组织VEGF阳性率分别为61.7%和7.7%,差别具有统计学意义(P<0.05);宫颈癌组织MVD计数显著高于慢性宫颈炎组织(45.38±10.28 VS 5.10±1.12,P<0.05);VEGF及MVD表达与肿瘤淋巴转移、临床分期及分化程度显著相关(P<0.05),而与年龄、病理分型无相关性(P>0.05)。结论宫颈癌组织VEGF及MVD表达显著升高,且与肿瘤的侵袭性密切相关,二者高表达患者预后不良。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and its microvessel density (MVD) and the invasion and metastasis of cervical cancer. Methods Immunohistochemistry was used to detect the expression of VEGF and MVD in 52 cases of chronic cervicitis and 60 cases of cervical cancer. Results The positive rates of VEGF in cervical cancer and chronic cervicitis were 61.7% and 7.7%, respectively, with statistical significance (P <0.05). MVD in cervical cancer was significantly higher than that in chronic cervicitis (45.38 ± 10.28 VS 5.10 ± 1.12, P <0.05). The expressions of VEGF and MVD were significantly correlated with lymphatic metastasis, clinical stage and differentiation (P <0.05), but not with age and pathological type (P> 0.05). Conclusion The expression of VEGF and MVD in cervical cancer tissues is significantly increased, which is closely related to the invasiveness of the tumor. The patients with high expression of VEGF and MVD have a poor prognosis.