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目的探讨睾丸精原细胞瘤的治疗和预后之间的关系。方法回顾性分析山东省肿瘤防治研究院１９６３年７月～１９９５年１１月收治的精原细胞瘤患者１２４例，其中，Ⅰ期精原细胞瘤患者仅做精索高位结扎睾丸切除加髂－腹主动脉旁淋巴引流区放射治疗；Ⅱ、Ⅲ期精原细胞瘤术后给予放疗及有计划地加用辅助性化疗。结果Ⅰ、Ⅱ、Ⅲ期精原细胞瘤５年生存率分别为９５．９％、７０．４％、和０。结论Ⅰ期精原细胞瘤患者仅做精索高位结扎睾丸切除加髂－腹主动脉旁淋巴引流区放射治疗可以治愈；而对Ⅱ、Ⅲ期病例单用睾丸切除加淋巴引流区放射治疗是不够的，为改善Ⅱ、Ⅲ期精原细胞瘤患者的预后，在预防性／根治性照射后，有计划的加用辅助性化疗是必要的。
Objective To explore the relationship between the treatment and prognosis of testicular seminoma. Methods A retrospective analysis of 124 cases of patients with seminoma from July 1963 to November 1995 in Shandong Academy of Oncology, in which patients with stage Ⅰ seminoma only had high ligation spermatic rupture and iliac-abdominal Radiotherapy of paraaortic lymphatic drainage area; Ⅱ, Ⅲ seminoma after radiotherapy and chemotherapy plus adjuvant chemotherapy. Results The 5-year survival rates of stage Ⅰ, Ⅱ and Ⅲ seminoma were 95.9% and 70.4%, respectively. Conclusions Stage I seminoma patients can only be cured by high-sperm ligation orchiectomy combined with radiotherapy of iliac-abdominal aortic lymph node drainage area. However, radiotherapy of single-stage orchiectomy plus lymphatic drainage in stage II and III patients is not enough , In order to improve the prognosis of patients with stage II and stage III seminoma, it is necessary to add adjuvant chemotherapy in a planned manner after prophylactic / radical irradiation.