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Ant malarial drug resistance exists whenadequate drug blood concentration are to kill apreviously susceptible parasite.This occurs byevolutionary selection of spontaneously arising mutantparasites that are drug insensitive.Drug resistance isoften,but not always,due to point mutations thatchange drug accumulation/efflux in the erythrocyte orreduce affinity for target molecule.Drug resistancecan present in several ways to include:failure oftreatment to clear parasites in a single patient,increasein malaria prevalence,malaria occurring in areas
Ant malarial drug resistance exists whenadequate drug blood concentration are to kill apreviously susceptible parasite.This occurs byevolutionary selection of spontaneously arising mutantparasites that are drug insensitive. Drug resistance isoften, but not always, due to point mutations thatchange drug accumulation / efflux in the erythrocyte orreduce affinity for target molecule. Drug resistancecan present in several ways to include: failure oftreatment to clear parasites in a single patient, increasein malaria prevalence, malaria occurring in areas