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目的探讨ATP结合盒G亚组成员1(ABCG1)的基因多态性与缺血性脑卒中的相关性。方法采用病例-对照方法,在中国北方汉族人群中收集389例缺血性脑卒中患者(病例组)与380名正常体检者(对照组)进行对照研究。按改良的TOAST分型将病例组分为动脉粥样硬化血栓形成型亚组(207例)和小动脉闭塞型亚组(182例),采用聚合酶链式反应-连接酶检测方法测定ABCG1基因rs225374位点的多态性。结果在动脉粥样硬化血栓形成型亚组,rs225374位点GG基因型和G等位基因分布频率显著高于对照组(25.6%vs 17.9%,P=0.030;49.8%vs 43.4%,P=0.037);小动脉闭塞型亚组与对照组比较,rs225374位点的基因型和等位基因分布频率差异无显著性。结论 ABCG1基因rs225374位点的多态性与中国北方汉族人群动脉粥样硬化血栓形成性缺血性脑卒中的发病具有一定相关性。
Objective To investigate the association between gene polymorphism of ATP binding cassette G subgroup 1 (ABCG1) and ischemic stroke. Methods A case-control study was conducted in 389 ischemic stroke patients (case group) and 380 normal subjects (control group) in a Han Chinese population of northern China. According to the modified TOAST classification, the cases were divided into atherothrombosis subgroup (207 cases) and arteriolar occlusion subgroup (182 cases). The ABCG1 gene was detected by polymerase chain reaction - ligase assay rs225374 polymorphism. Results In the atherosclerotic thrombosis subgroup, the frequency of GG genotype and G allele at rs225374 was significantly higher than that of the control group (25.6% vs 17.9%, P = 0.030; 49.8% vs 43.4%, P = 0.037 ). There was no significant difference in genotype and allele frequency between rs225374 locus and control group. Conclusion The rs225374 polymorphism of ABCG1 gene is associated with the incidence of atherothrombotic ischemic stroke in Han population of northern China.