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目的观察环磷腺苷联合美托洛尔治疗充血性心力衰竭的临床疗效。方法将60例随机分为A、B二组,A组采用常规抗心力衰竭治疗的强心、利尿、扩管基础方法,B组在常规治疗基础上加用美托洛尔注射液5mg加入5%葡萄糖注射液100ml中,静脉滴入,1次/d,环磷腺苷针60mg加入5%葡萄糖注射液250ml中静脉滴入,1次/d;连续10d,治疗前后分别观察心率、收缩压、舒张压、左室舒张末期内径(LVD)、左室收缩末期内径(LVs)、左室射血分数(EF)。结果二组治疗前各指标差异无统计学意义(P>0.05);治疗后B组心率、血压、LVEF、LVEDd均有显著改善(P<0.01);而A组只有心率、LVEF较治疗前明显改善(P<0.05),且B组优于A组(P<0.05)。结论在应用抗心力衰竭常规治疗基础上结合环磷腺苷联合美托洛尔可有效改善心功能、提高生活质量,值得临床推广。
Objective To observe the clinical efficacy of cyclic adenosine monophosphate combined with metoprolol in the treatment of congestive heart failure. Methods Sixty patients were randomly divided into two groups: A and B, group A was treated with conventional heart failure, diuresis and expansion based on heart failure. Group B received metoprolol injection 5 mg % Glucose injection 100ml, intravenous infusion, 1 / d, 60mg of cyclophosphamide needle added 5% glucose injection 250ml intravenous infusion, 1 / d; continuous 10d, before and after treatment were observed heart rate, systolic blood pressure , Diastolic blood pressure, left ventricular end-diastolic diameter (LVD), left ventricular end-systolic diameter (LVs) and left ventricular ejection fraction (EF). Results There was no significant difference in each index between the two groups before treatment (P> 0.05). The heart rate, blood pressure, LVEF and LVEDd in group B were significantly improved after treatment (P <0.01) (P <0.05), and group B was better than group A (P <0.05). Conclusions The combination of cyclic adenosine monophosphate and metoprolol can effectively improve heart function and improve the quality of life on the basis of routine treatment of heart failure, which is worthy of clinical promotion.