论文部分内容阅读
发育性髋关节脱位(developmental dislocation of the hip,DDH)是小儿骨科最常见的、严重危害儿童健康的先天性畸形之一。目前学者们认为DDH是一种复杂的多基因病,是遗传因素和环境因素共同作用的结果,但其具体病因不清。环境因素包括宫内环境及生后环境因素,前者如臀位妊娠、羊水过少等,后者如不恰当的襁褓方式,髋关节被异常地牵拉等[1]。流行病学调查显示,约有12%~33%的DDH患儿有阳性家族史[2~4]。目前DDH分子遗传学研究主要采取
Developmental dislocation of the hip (DDH) is one of the most common congenital malformations in pediatric orthopedics that seriously endangers children’s health. At present scholars think DDH is a complex polygenic disease, genetic factors and environmental factors together, but the specific cause is unclear. Environmental factors include the intrauterine environment and postnatal environmental factors, the former such as breech pregnancy, oligohydramnios, etc., which is not properly coveted, the hip was pulled anomalously [1]. Epidemiological survey shows that about 12% to 33% of children with DDH have a positive family history [2-4]. The current DDH molecular genetics research to take