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目的 观察大鼠脑出血后延髓内脏带儿茶酚胺能神经元的 Fos表达 .方法 尾壳核局部注射胶原酶制作脑出血模型 ,用抗 Fos蛋白和抗酪氨酸羟化酶 (TH)的双重免疫组织化学方法 (ABC法 ) ,观察延髓内脏带内 Fos蛋白表达及其与TH阳性神经元的共存 .结果 有大量的 Fos阳性细胞出现在延髓内 ,它们主要局限在延髓内脏带内 ,并以孤束核 (NTS)与延髓腹外侧区 (VL M)较为密集 .NTS和 VL M内 Fos/ TH双标细胞占 TH阳性细胞的比例分别为 19.2 9%和 6 9.0 0 % .单纯注射生理盐水大鼠只有少量的 Fos表达 ,未见双标细胞 .结论 脑出血急性期延髓内脏带内 Fos表达阳性神经元以及儿茶酚胺能神经元表达 Fos,可能与脑出血后植物神经系统功能紊乱有关 .
Objective To observe the Fos expression of catecholaminergic neurons in the medullary visceral zone after intracerebral hemorrhage in rats.Methods The model of intracerebral hemorrhage was induced by local injection of collagenase into the caudate putamen nucleus.Each anti-Fos protein and anti-tyrosine hydroxylase (TH) (ABC method) was used to observe the expression of Fos protein in the medullary visceral zone and its coexistence with TH positive neurons.Results A large number of Fos positive cells appeared in the medulla oblongata.They were mainly confined to the medullary visceral zone, (NTS) and rostral ventrolateral medulla (VL M) were more dense.The percentages of Fos / TH double positive cells in TH and NTS were 19.29% and 6.90% respectively.Normal saline injected rats Only a small amount of Fos expression, no double-labeled cells.Conclusion Fos positive neurons and catecholaminergic neurons in the medullary visceral zone of acute cerebral hemorrhage may be related to dysfunction of autonomic nervous system after intracerebral hemorrhage.