作者经光镜及电镜形态观察发现,用三七皂甙R_180μg/ml处理5日,可诱导68％的HL—60细胞分化,其中晚幼粒32％,杆状30％,分叶6％。经药物诱导前HL—60细胞为圆形或不规则椭圆形,核大而圆,胞浆少而染色浅,95％细胞呈原粒及早幼粒形状;经药物诱导后HL—60细胞胞体明显变小,核质比例降低,核形状不规则,出现肾形杆状及分叶核。首次证实三 The authors observed by morphological observation under light microscope and electron microscope found that treatment with panax notoginseng R_180μg/ml for 5 days induced differentiation of HL-60 cells with 68%, of which 32% were late seedlings, rods were 30%, and leaves were 6%. The HL-60 cells were round or irregularly oval before drug induction. The nucleus was large and round with few cytoplasms and light staining. 95% of the cells were of primary granules and shape of early granules. The HL-60 cell bodies were obviously induced by drugs. When it becomes smaller, the proportion of nucleoplasms decreases, the shape of the nucleus is irregular, and the kidney-shaped rods and the lobulated nucleus appear. First time to confirm three