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目的:探讨采取瞬时弹性成像技术(TE)评估长期口服抗病毒药物对慢性乙型肝炎患者的肝脏硬度(LSM)变化及临床价值。方法:采用前瞻性研究方法,分析2010年1月-2012年12月收治的口服抗病毒药物治疗的慢性乙型肝炎患者60例的临床资料。结果:60例慢性乙型肝炎患者的平均治疗时间间隔为(325.6±124.1)d,治疗后的LSM显著低于治疗前[(10.3±6.1)kPa vs(17.2±11.5)kPa,P<0.001],治疗后LSM改善的患者有32例(53.3%)。结论:长期口服抗病毒药物可有效改善慢性乙型肝炎患者的肝纤维化,TE是评估慢性乙型肝炎患者疾病进展的有用临床工具之一。
Objective: To investigate the changes of liver stiffness (LSM) and clinical value of long-term oral antiviral drugs in patients with chronic hepatitis B by using transient elastography (TE). Methods: A prospective study was conducted to analyze the clinical data of 60 patients with chronic hepatitis B who were treated with oral antiviral drugs from January 2010 to December 2012. Results: The mean duration of treatment was (325.6 ± 124.1) days in 60 patients with chronic hepatitis B. The LSM after treatment was significantly lower than that before treatment [(10.3 ± 6.1) kPa vs (17.2 ± 11.5) kPa, P <0.001) There were 32 patients (53.3%) with improved LSM after treatment. Conclusion: Long-term oral antiviral drugs can effectively improve liver fibrosis in patients with chronic hepatitis B. TE is one of the useful clinical tools to evaluate the progress of disease in patients with chronic hepatitis B.