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目的:观察六味安消联合曲美布汀对便秘型lBS的治疗效果。方法:选符合罗马Ⅱ诊断标准的便秘型IBS患者136例,随机分为3组:联合组50例,联合应用六味安消胶囊和马来酸曲美布汀胶囊;曲美布汀组46例,单用马来酸曲美布汀胶囊;六味安消组40例,单用六味安消胶囊。疗程为6周,观察3组腹胀、腹痛、便秘、残便感的缓解情况。结果:联合组的显效率和总有效率分别是50.0%和88.0%,而曲美布汀组是17.4%和63.0%,六味安消组是15.0%和60.0%,联合组与其它两组疗效有显著性差异(P<0.05),而3组的不良反应差异无显著性(P>0.05)。结论:联合使用六味安消和马来酸曲美布汀可提高便秘型IBS患者腹胀、腹痛、便秘、残便感的缓解率,值得临床推广应用。
Objective: To observe the therapeutic effect of Liuwei Anshun combined with trimebutine on constipation type lBS. Methods: One hundred and sixty-six patients with constipation-type IBS who meet the diagnostic criteria of Rome Ⅱ were randomly divided into three groups: combination group (50 cases) combined with Liuwei Anxiao capsule and trimebutine maleate capsules; , Trimebutine maleate capsules alone; Liu Wei Anshun 40 cases, alone Liuwei Anxiao capsules. The course of treatment was 6 weeks. The relief of abdominal distension, abdominal pain, constipation and residual diarrhea were observed in 3 groups. Results: The effective rate and total effective rate in the combination group were 50.0% and 88.0% respectively, compared with 17.4% and 63.0% in the trimebutine group and 15.0% and 60.0% in the Liuweianxiao group, respectively There was significant difference (P <0.05), but there was no significant difference between the three groups (P> 0.05). Conclusion: The combined use of Liu Wei Anshine and trimebutine maleate may improve the constipation-induced IBS patients with abdominal distension, abdominal pain, constipation, residual ease the rate of response, worthy of clinical application.