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目的探讨局部注射曲安奈德配合综合心理干预治疗老年人糜烂型口腔扁平苔藓(OLP)的疗效。方法对44例老年糜烂型OLP患者根据经济情况分为2组,干预组联合治疗前后检测T淋巴细胞亚群的变化并观察临床疗效指标,对照组只局部注射曲安奈德。结果干预组病例糜烂面积控制和临床症状缓解的总有效率明显高于对照组(P<0.05),T淋巴细胞亚群检测CD3+、CD4+T细胞升高(P<0.01),CD8+T细胞下降(P<0.01),CD4+/CD8+治疗后上升(P<0.01)。结论心理干预治疗与药物联合应用能有效改善糜烂型OLP不良状况,增强药效,从而缩短治疗时间,对OLP的最终治疗效果有促进作用。
Objective To investigate the curative effect of local injection of triamcinolone acetonide combined with comprehensive psychological intervention on elderly patients with erosive oral lichen planus (OLP). Methods Forty-four elderly patients with OLP were divided into two groups according to the economic conditions. The changes of T lymphocyte subsets in the intervention group before and after the combination therapy were observed and the clinical efficacy indexes were observed. The control group was only injected with triamcinolone acetonide locally. Results The total effective rate of erosive area control and clinical symptom relief in the intervention group was significantly higher than that in the control group (P <0.05). The levels of CD3 + and CD4 + T cells were increased in T lymphocyte subsets (P <0.01) (P <0.01), but increased after CD4 + / CD8 + treatment (P <0.01). Conclusion The combination of psychological intervention and drug can effectively improve the erosive OLP, improve the efficacy, shorten the treatment time and promote the final treatment effect of OLP.