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目的探讨重症急性胰腺炎(SAP)患者血清IL-17、IL-17R、IL-6、HMGB1及IL-10水平的变化和临床意义。方法研究对象包括29例正常对照患者和54例重症急性胰腺炎患者,患者组根据是否并发多器官功能障碍综合征(MODS)分为MODS组和非MODS组。采用ELISA试剂盒检测HMGB1、IL-17、IL-17R、IL-6、IL-10水平。结果SAP患者IL-17、IL-17R、IL-6水平均高于正常对照组,而IL-10低于正常对照组,差异均具有统计学意义(P<0.05)。正常对照组HMGB1为阴性,SAP患者显著升高。MODS组IL-6、IL-17、IL-17R、HMGB1水平高于非MODS组,而IL-10低于非MODS组,差异均有统计学意义(P<0.05)。结论重症急性胰腺炎患者血清促炎细胞因子升高,抑炎细胞因子降低,晚期炎症介质显著升高,可能存在炎症细胞因子网络失衡,与疾病的严重程度相关。
Objective To investigate the changes and clinical significance of serum IL-17, IL-17R, IL-6, HMGB1 and IL-10 in patients with severe acute pancreatitis (SAP). Methods The subjects included 29 patients with normal control and 54 patients with severe acute pancreatitis. Patients were divided into MODS group and non-MODS group according to whether they had multiple organ dysfunction syndrome (MODS). The levels of HMGB1, IL-17, IL-17R, IL-6 and IL-10 were detected by ELISA kit. Results The levels of IL-17, IL-17R and IL-6 in SAP patients were significantly higher than those in normal control group, while the levels of IL-10 in SAP patients were lower than those in control group (P <0.05). The normal control group HMGB1 was negative, SAP patients were significantly higher. The levels of IL-6, IL-17, IL-17R and HMGB1 in MODS group were higher than those in non-MODS group, while the levels of IL-10 in MODS group were lower than those in non-MODS group (P <0.05). Conclusions Serum levels of proinflammatory cytokines, proinflammatory cytokines and advanced inflammatory mediators in patients with severe acute pancreatitis may be increased. There may be an imbalance of inflammatory cytokines network, which may be related to the severity of the disease.