在葡萄糖香草醛结构－ 活性相关性研究中，进行了葡萄糖香草醛的合成工作。以溴代四乙酰葡萄糖和香草醛为原料，溴化四丁基铵为催化剂，采用相转移催化法进行糖甙化反应以９２ ％ 的收率得到四乙酰葡萄糖香草醛，经脱保护基后得到葡萄糖香草醛。产物结构经元素分析、红外光谱、核磁共振谱所证实。 In the glucose-vanillin structure-activity correlation studies, the synthesis of glucose vanillin was performed. Tetraacetylglucosamine vanillin was obtained in 96% yield by brominated tetraacetylglucose and vanillin as raw materials and tetrabutyl ammonium bromide as catalyst. The glycosylation reaction was carried out by phase transfer catalysis. After deprotection, Glucose vanillin. The structure of the product was confirmed by elemental analysis, infrared spectrum and nuclear magnetic resonance spectrum.