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应用ＰＡＰ免疫组织化学技术对胃泌素（ｇａｓｔｒｉｎ，ＧＡＳ）和５羟色胺（ｓｅｒｏｔｏｎｉｎ，５ＨＴ）在胃癌和慢性萎缩性胃炎（ＧＡＳ）中表达的免疫反应性（ＩＲ）进行了研究。结果：在正常胃粘膜ＧＡＳＩＲ（２６．５±６．２）明显高于５ＨＴＩＲ（９．２±４．３）。ＧＡＳＩＲ和５ＨＴＩＲ在胃癌明显高于正常组织。在ＣＡＧ，ＧＡＳＩＲ和５ＨＴＩＲ均显著高于正常组织（Ｐ均＜０．０１）。ＧＡＳＩＲ在低分化癌中表达增强，而５ＨＴＩＲ与胃癌的分化类型无明显相关性（Ｐ＜０．０５）。结果提示：ＧＡＳ和５ＨＴ均参与胃癌发生发展的内分泌调节，ＧＡＳ在肿瘤细胞分化过程中可能起重要作用。ＧＡＳＩＲ和５ＨＴＩＲ在ＣＡＧ中的高表达，是否与其恶性变有关，值得进一步探讨。
PAP immunohistochemistry was used to study the immunoreactivity (IR) of gastrin (GAS) and serotonin (5HT) expressed in gastric cancer and chronic atrophic gastritis (GAS). Results: In the normal gastric mucosa GAS IR (26.5 ± 6.2) was significantly higher than 5 HT IR (9.2 ± 4.3). GAS IR and 5 HT IR in gastric cancer was significantly higher than normal tissues. In CAG, GASIR and 5HTIR were significantly higher than normal tissues (all P <0.01). GAS IR expression in poorly differentiated cancer increased, while 5 HT IR and gastric cancer differentiation type was not significantly correlated (P <0.05). The results suggest that: GAS and 5 HT are involved in the development of endocrine regulation of gastric cancer, GAS may play an important role in tumor cell differentiation. GAS IR and 5 HT IR in CAG high expression, whether with its malignant transformation, it is worth further study.